PDRN in Private Label Skincare

Polydeoxyribonucleotide (PDRN) has emerged as a revolutionary ingredient in skincare, celebrated for its regenerative and anti-aging properties. Derived from DNA fragments, PDRN is primarily used to enhance skin repair, boost collagen production, and improve overall skin health. Traditionally sourced from salmon sperm (Salmon PDRN) due to its biocompatibility with human DNA, newer alternatives have gained in popularity, particularly for natural, cruelty-free and sustainable skincare enthusiasts but not all of them are effective. PDRN is another clinical grade Key ingredient used in our Private Label Skin Care range.

Benefits of PDRN in Skincare

PDRN works by activating the adenosine A2A receptor, which promotes cell proliferation, reduces inflammation, and stimulates angiogenesis (new blood vessel formation). It also stimulates the secretion of VEGF, which facilitates the formation of new blood vessels, and promotes the secretion of EGF/VEGF/IGF growth factors aiding in tissue regeneration. These mechanisms contribute to several key benefits:

1. Skin Regeneration and Repair: PDRN accelerates cell turnover and tissue repair, making it ideal for healing acne scars, burns, or post-procedure damage from treatments like microneedling or laser therapy.

   
   

2. Anti-Aging: By stimulating fibroblast activity, PDRN boosts collagen and elastin production, reducing fine lines, wrinkles, and sagging for firmer, more youthful skin.

   
   

3. Hydration and Barrier Strengthening: PDRN enhances moisture retention and strengthens the skin barrier, benefiting dry or sensitive skin types.

   
   

4. Anti-Inflammatory Properties: It soothes redness and irritation, making it suitable for sensitive or compromised skin.

   
   

5. Improved Skin Texture and Radiance: PDRN promotes a smoother, more even complexion by addressing hyperpigmentation and dullness.

   
   

These benefits make PDRN a versatile ingredient, particularly when paired with procedures like microneedling, which enhances its absorption into deeper skin layers.

Types of PDRN

Salmon PDRN

Salmon PDRN, extracted from salmon sperm or testes, is the most researched form of PDRN. Its DNA fragments, ranging from 50 to 1500 kDa, closely resemble human DNA, ensuring high biocompatibility. This similarity allows Salmon PDRN to effectively engage A2A receptors, promoting tissue repair and collagen synthesis. Clinical studies have shown it excels in wound healing, reducing inflammation, and improving skin elasticity, particularly when injected or applied along with microneedling. Its larger molecular size however can limit topical absorption without procedures like microneedling to create microchannels or by injection and thus it is generally not recommended for transdermal creams and gels.

Microbial Based PDRN

We use a PDRN which is extracted from the probiotic Lactobacillus, being an alternative designed for vegan-friendly skincare and those concerned with sustainability. It mimics Salmon PDRN’s regenerative properties by activating A2A receptors and supporting DNA salvage pathways as well as stimulating the secretion of VEGF and other growth factors. Recent studies suggest it offers superior antioxidant, skin regenerative and anti-inflammatory effects compared to Salmon PDRN possibly due to its lower molecular weight (8 times smaller than Salmon PDRN) enhancing topical absorption, making it effective in serums without requiring microneedling or injections. Both in vitro and in vivo studies are available which supports it use and effectiveness.

Plant Based PDRN

Various plant sources of PDRN are now becoming popular. Four plant based PDRN products on the market (Aloe, Cactus, Curcuma, Centella Asiatica) were tested by DNA electrophoresis and NO DNA band was found even at 30X concentration which highly questions their quality and effectiveness. When comparing Lacto-PDRN with plant based PDRN comparison testing shows the DNA content in Lacto-PDRN is far greater than plant based PDRN (over 100X) while plant based PDRN has a lot of non DNA impurities. At this stage based on this information we do not recommend the use of plant based PDRN unless the manufacturer can prove the DNA content and provide in vitro and in vivo studies to support its use.

Absorption and Efficacy

Salmon PDRN’s larger molecular size means it relies on microneedling or injections for optimal penetration, leading to robust results in clinical settings (e.g., reduced acne scarring and improved elasticity). Microbial PDRN, with its smaller molecular structure, is better suited for topical application, offering quicker absorption and gentler effects, ideal for daily use. While Salmon PDRN has a stronger evidence base for therapeutic outcomes, Lacto-PDRN’s hypoallergenic and non-comedogenic properties make it suitable for sensitive skin, with emerging data supporting its role in hydration and barrier repair. We do not recommend plant based PDRN at this point.

Conclusion

PDRN is a game-changer in skincare, offering regeneration, anti-aging, and hydration benefits. Salmon PDRN, with its proven track record, excels in clinical injection treatments, while microbial based PDRN provides a vegan, sustainable and superior absorption when used in daily skin cream/serum routines. Here at Private Label Cosmeceuticals we have chosen to use Lacto-PDRN form as a star ingredient in a number of our white label products.